Salmo, the replication crisis is not the studies do not get attempts to replicate them, it's that when the attempt is made that they get a different result.

Nobody expects absolute certainly, but the same people that push "trust the science" often have no real data to support their claims. People like Fauci says to question him is questioning science are painting people as science deniers. When Fauci, lies and flip-flops and of course can be questioned. Good science can stand questioning, it's a good sign that when you question the science and it stands up that it is likely true. When you have to resort to fallacious arguments, name calling, painting the questioners as denying or outright censoring them it is likely false.

The biggest science deniers are those from the left, denying basic biology of the number of genders & evolutional biology because they are politically incorrect.