I carry either my S&W Model 4506, or my Colt 1911 (both are .45). I'm a fairly big guy, so concealment isn't a problem. I like to use a shoulder holster for concealability reasons. I use Glazer Safety Slugs and hollow points. I chose the .45 because it's a tried and true round that has been around forever. Hey if it was good enough for our military for so many years, then it good enough for me.
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If you get home and I'm not there, don't eat it.