I don't have any experience doing what you are talking about, but think you'll have problems with the clips holding the line. You might be able to switch clips to one that allow adjustment for line diameter.

I tried PowerPro on a couple rods a few years back, but ended up going back to mono. I found the line to be very unforgiving and I ended up losing several fish before I got the hang of it. With a downrigger rod if a fish smacks the lure hard mono seems to take a lot of the shock, but even then I've seen fish broken off. I'd been concerned you might have more of a problem with PowerPro

Just my $0.02 worth.