A buddy of mine used to manage a ranch that had some buffalo on it and we whacked a few of them with a bow. They are pretty darn tough critters and we did have to shoot one twice which ended up with us scrambling for the trees only to watch him tip over in a full run. I would not shoot one past 40 yards if it was me. They die like everything else if you shoot them in the right spot. One thing....when a herd of them critters smell blood...they get pretty mily..running around snorting..acting all wierd and not so friendly...I have seen that more than once as well...