Hey-
This topic came up on another board I use. I spent many hours fishing muskie in the midwest I would second a lot of what kjackson had to say. I disagree on one tiny point. Since these fish are extremely hard to raise and hook I would not worry about my flies only lasting one fish. I would gladly let them rip it up if I think it is going to work well. Other than that see below for my post on the other board I use. Good luck and let us know how it goes.
"Finally a topic I know something about! I used to fish extensively for muskie while I grew up in Wisconsin and Minnesota and have caught about 100 of them. I have used both conventional gear and a fly rod. While I cannot say I have landed one on a fly rod I have had several hard takes and I can tell you it feels like a hand grenade going off on the end of your line when it happens. Quite exhilirating to say the least. In the midwest muskie like the gawdiest things. Chartreuse green, red, red and yellow, red and brown all catch fish. Crippled looking fish are really an obvious choice. Retrieve accordingly (ie. eratic and jerky). Also, I have been able to see almost every bite I have had from muskie so don't worry about getting too deep, they like noise and flash and will come up a ways to hit it. They like to lay in weeds and ambush from there. I don't know if air craft cable is necessary for tippet. Notice I haven't landed one but I can all but gurantee lighter will mean more hookups and they are extremely resilient fish, if they end up with your fly in their mouth they will shake it or live through it. If you are fortunate enough to hook one in the corner of the mouth you can get by with quite light line but if you get in to their teeth they will be waving good bye in a hurry. I don't know how active they will be in the winter, check your water temps and then check them against the more productive months in WI and MN lakes. Good luck. Email me if you want to know anything. I may or may not be able to help."
Later
Josh
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JRD Steelieblue