I certainly don't have the perfect boat for that fishery but it would work. I've caught quite a few but that was in Minnesota with my uncle. He had it dialed. His pictures were in all the magazines. The fishery out here is probably quite a bit different. An 8 wt or heavier with some sort of shooting head system would probably work. Not because of the fish but the crap you'll be casting. You'll spend your time stripping fairly fast so you pretty much just want to get it back out there. Early in the season they might be a little lethargic because of the cooler water so an intermediate might come in handy, Also, a 15-20' fast sinking head for keeping it down a few feet while stripping. He's hit lots of fish over 50". 44" back there is considered big. All of his fishing was with gear and most of mine was too. But, I landed 7 or 8 on the flyrod, biggest going 47". He knew exactly where they lived which was the key to me being able to hook up on the fly.
Heavy 6 foot leader. 8" of wire to the fly. Blacks, yellows, maybe a bit of chartreuse tied deceiver style would work. 4-6" flowing hackles or even just some big bunny leaches tied in a variety of colors. Lots of bass and panfish in the lake so maybe stuff colored like a smallmouth or perch?
Best way to fish it would probably throw the float tubes or water master in the boat and go find some good water. Drop anchor, jump in the little boats and kick around fishing the good stuff.
Mayfield is a place I'd like to try also.
Check this out.
http://www.lostcreekflies.com/category/Tiger-Muskie-Pike-Flies-89