The up sides of the centre pin system are two fold. One, the drag free drift ability of the reel. And two, the line management capability of the long rod. Even with those two factors working at their maximum capability, the centre pin system, in my opinion, is still putting the user at a bit of a disadvantage over other options for casting, retrieving, and line/gear management. Take one of those away, such as rod length, and you are even farther into the hole.

That having been said, style is usually a factor and catching a fish in spite of odds stacked in the opposite direction, can be very rewarding and certainly bears merit for those in search of such an experience.

You can fish a fly on a spinning rig, you can fish drift gear on a fly rig, and you can certainly use a centre pin reel on any number of rods. However, on a macro level, matching your gear to your method based on generally accepted norms and in some cases refined data, is usually the best and most efficient way to go. On a finer level, there are those that could make strong arguments on many finer points within a given discipline, and such a proposition, to them, would seem a bit ludicrous. Oil and water so to speak.

Personally, the path is but part of the reward, the end result another. Lots of other variables along the way.