Banock,
First, I'm flattered you would ask my opinion. I'm not a guide and about the only expertese I can claim to is I've gone out a few times with guides. So just my observations, and maybe some fellow readers can give theirs.
Number one, I hope you REALLY like fishing and people. Because you'll be in a boat for eight hours with 2-3 people you've never met before. Sometimes even with friends I'm ready to get off my boat after 6-7 hours! Second, do you want to turn your hobby into your job? Because it's got to change things, at least for the days you have clients. I've been with guides that are great and guides that are just putting in the time. Not very fair to charge someone $110 and not give them 8 hours of your attention and experience. Third, are you ready for a tough business to make a buck in? It may sound like fun to fish all day and get paid, but as I'm sure you know there are lots of hidden expenses - lost gear, busted rods, you name it. Don't forget insurance. Have someone get hurt on your boat and expect to get sued. Sad but that's the way it is.
As far as a guide service in the area you talked about, I wonder how much disposable income is in that area? You're talking about poor counties with high unemployment.
I'm not trying to rain on your idea, but sometimes it helps to hear the downside.
My opinion is, if you take everything into consideration and still want to try it, then GO FOR IT. There's nothing better than making a living (or even adding some extra income) doing something you love. I'd be interested to know what you decide and if I can help promote you on this end I'm happy to help.
What about it fellow readers - anything else you think Banock should think about?