I used to get sick every now and then when I was young. As I got older, I did the Dramamine thing, and had good success. Then about 8 years ago, I went out with a friend on his commercial troller for salmon. Fog so thick you couldn't see 50', and that 42' wooden double ender was burping diesel exhaust and was bobbing like a cork on the big swells. About mid way into the day, I just layed down on the deck and chummed out one of the scupper slots. A few hours later I couldn't stand, and my buddy headed in. I layed on the dock for a good hour, but when I got in my truck, it was obvious there was no way I could make the hour drive home. Went to a flea bag joint in Newport and continued to puke all night. Drove home the next day, but was still too sick to eat until day three. The most horrible experience I have ever been through.

*But* since this experience I have never again been sick, nor had to take any form of medication. I somehow purged the curse of seasickness from my body that day.