I'm defining pre-contact as before the "Hudson Bay company, British Royal Navy and US Navy" made contact with the tribes "up and down the coast north of the Columbia river and in the Puget Sound." If I was talking about prior to the 1500's, I would have said "pre-Columbian." Most likely smallpox spread in the Pacific Northwest by 1520 from Indian to Indian contact but this is not conclusively proven. What is conclusively proven is nobody was handing out smallpox blankets "up and down the coast north of the Columbia river and in the Puget Sound" and certainly not "Hudson Bay company, British Royal Navy and US Navy."