For some reason, fishing from a boat with a right-hand crank feels fine, but if I am casting and retrieving, I prefer the left-hand retrieve.

I also chop wood left handed, but like Piper, I look pretty goofy throwing left-handed.

Once I get the fish to the boat, or shore, I always use my dominant right hand to deal with the fish. When fighting the fish with both hands on the rod it's easy to take your right hand off to deal with the fish.