I'd say don't go out with B-run. I've only been sick once in my life as a kid I sat where the diesel blew in my face going over a particularly rough Westport bar. But I've been in 20 foot swells in a skiff and had a blast watching land, no land, land, no land....(feeling Ok B-run?).
I've also heard ginger works but you'd think it would taste awful. The worst is if one person on the boat gets sick then it seems to spread. Don't look at a sick person.
Speaking of B-run....my dad and I were on a neighbors Westport charter 30 years ago and there was an old man with a cheese sandwich in one hand and the other hand he'd use to pull his false teeth out to puke, put the dripping teeth back in and take a bite out of the cheese sandwich. Now watching this guy we both almost lost it. I felt like just throwing him overboard and ending his misery. And for me beer is the best on a real rough day.