I have a knight bighorn. My whole party uses 110 grain pyrodex with a 400 grain bullet. We started at 150 grains of powder and loaded down untill we got the accuracy we wanted and flames stopped shooting 3 feet out the barrel.
@ 100 yards you can hit a 4 inch plate, 150 6 inch plate, and beyond that i will not shoot. I am confident i would hit it but just to many variables. I think all the bullets expand very well, we shot different bullets into phone books @ 100 yards. They penetrated through 4 books before they stopped, all were flat and held together. What was funny is my brother shot those phone books with his 270 from the same distance, and the bullet penetrated 4 books, just like the ML bullets it just didn't hold together as well.. The dead center penetrated the deepest buy 3/4 of an inch.