Rl-15 is all I use in my 22-250. Varget works too. KeeP your eyes on cabelas. Powder has become a real haste. Stock up if you can. Like dogfish...I don't do the research like I use to. I use what I have on hand. My last couple 22-250s were very tempramentle, but what worked..really worked good. Varget with a 52gr Speer hollow point. Not TNT. RL 15 and a 55vmax is my rodent load, and RL15 with a 60 Sierra hp for dogs.