No.

Any junctions, loops or knots, will create noticeable drag running through your guides, but you should be casting with all of these junctions well outside of your guides with the exception of perhaps your backing knot if you have one. You won't notice any loss of distance due to aerodynamics.
_________________________
I am still not a cop.

EZ Thread Yarn Balls

"I don't care how you catch them, as long as you treat them well and with respect." Lani Waller in "A Steelheader's Way."