I have both and use both. Hunting the island of the Snake river looking for ducks and pheasant means a lot of bushwacking that is far too hard on the breathable. Neoprene waders are easy to repair and so cheap that if I really trash a pair it doesn't matter that much. Breathables are great for all the reasons mentioned above and also are much lighter. I've backpacked in the Winds with waders and a lightweight float-tube. Neoprenes would have added a couple more lbs.