I don't know why more people aren't interested in the effect of the wind, assuming you have and accurate rifle and ammo, a lazer rangefinder, and some system of compensating for bullet drop, the only variables are shooter and wind (shooter's ability to read and compensate). Shooting a high B.C. bullet at a high velocity puts as much in your corner as you can get. Sure you can kill ______________with a .22 Hornet or an '06.........if you can hit it. How many days, in the fall, have you been up in the mountains and not had enough of a breeze to keep the bugs down ? Go to JBMballistics and plug in the data for your hunting load, and see how much a ten mph, full value, breeze will do to you at 500 yards. I like to think I will be able to guess the wind within 50% accuracy, but I'm not saying I can do it.